A novel effect of eicosapentaenoic acid: improved diaphragm strength in endotoxemia
نویسنده
چکیده
Respiratory muscle weakness is commonplace in critically ill patients, impairing the ability of those patients to breath, prolonging the need for ventilatory support, and increasing the likelihood of respiratory failure when that support is removed. Infections and endotoxemia reduce respiratory muscle strength, probably acting through several mechanisms. It is reported that the omega-3 fatty acid eicosapentaenoic acid (EPA) attenuates the loss in diaphragm specific force generation (that is, diaphragm strength) induced by bacterial endotoxin treatment in rats. EPA is found in fish oils. EPA reduces calpain activation, suggesting a specific effect on this proteolytic pathway. It will be important to identify whether this effect occurs in patients receiving EPA.
منابع مشابه
Eicosapentaenoic acid preserves diaphragm force generation following endotoxin administration
INTRODUCTION Infections produce severe respiratory muscle weakness, which contributes to the development of respiratory failure. An effective, safe therapy to prevent respiratory muscle dysfunction in infected patients has not been defined. This study examined the effect of eicosapentaenoic acid (EPA), an immunomodulator that can be safely administered to patients, on diaphragm force generation...
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